Alcaftadine

Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects[1][2].

Product Specifications

CAS Number

[147084-10-4]

Product Name Alternative

R89674

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Alcaftadine.html

Purity

98.37

Solubility

DMSO : ≥ 40 mg/mL

Smiles

O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC\4

Molecular Formula

C19H21N3O

Molecular Weight

307.39

Precautions

H315, H319, H335

References & Citations

[1]Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47 (12) : p. 883-90.|[2]Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46 (7-8) : p. 1025-32.