NSC 107512
NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9) . NSC 107512 is a class of sangivamycin-like molecules (SLM) . NSC 107512 inhibits growth and induces apoptosis of multiple myeloma tumors[1].
Product Specifications
CAS Number
[22242-89-3]
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-107512.html
Purity
99.97
Solubility
DMSO : 170 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(N)=C3C(C(NO)=N)=C2
Molecular Formula
C12H16N6O5
Molecular Weight
324.29
References & Citations
[1]Dolloff NG, et al. Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9. Mol Cancer Ther. 2012;11 (11) :2321-2330.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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