Z-Ala-Ala-Asn-AMC
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].
Product Specifications
CAS Number
149697-16-5
Product Name Alternative
Cbz-Ala-Ala-Asn-AMC
UNSPSC
12352209
Target
Fluorescent Dye
Type
Peptides
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-ala-ala-asn-amc.html
Purity
99.28
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N)C[C@@H](C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O)NC([C@H](C)NC([C@H](C)NC(OCC3=CC=CC=C3)=O)=O)=O
Molecular Formula
C28H31N5O8
Molecular Weight
565.57
References & Citations
[1]Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20 (3) :500-510.|[2]James C. Powers, et al. Propenoyl hydrazides. US7482379B2.|[3]Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23 (8) :1023-1035.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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