Z-Ala-Ala-Asn-AMC

Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].

Product Specifications

CAS Number

[149697-16-5]

Product Name Alternative

Cbz-Ala-Ala-Asn-AMC

UNSPSC

12352209

Target

Fluorescent Dye

Type

Peptides

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-ala-ala-asn-amc.html

Purity

99.28

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N)C[C@@H](C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O)NC([C@H](C)NC([C@H](C)NC(OCC3=CC=CC=C3)=O)=O)=O

Molecular Formula

C28H31N5O8

Molecular Weight

565.57

References & Citations

[1]Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20 (3) :500-510.|[2]James C. Powers, et al. Propenoyl hydrazides. US7482379B2.|[3]Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23 (8) :1023-1035.