GW3965 (hydrochloride)
Product Specifications
UNSPSC Description
GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].
Target Antigen
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/GW3965-hydrochloride.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4.[H]Cl
Molecular Weight
618.51
References & Citations
[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.|[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.|[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.|[4]Collins JL, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6.bioRxiv. 2023 Mar 10.|Radboud University Nijmegen. 2021 Mar.|Viruses. 2022, 14(3), 514.|Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. |Bioconjug Chem. 2015 Nov 18;26(11):2216-22. |Cancer Lett. 2023 May 5;216208.|Cell Death Differ. 2020 Aug;27(8):2433-2450. |J Am Heart Assoc. 2021 May 8;e018455.|J Ethnopharmacol. 2023 May 24;315:116684.|Sci Adv. 15 Jul 2022.|Theranostics. 2020 Jul 11;10(19):8834-8850. |Vet Microbiol. 2024 Jan, 288, 109948.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10627A/GW3965-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10627A/GW3965-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
405911-17-3
Available Sizes
Curated Selection
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