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GW3965 (hydrochloride)

GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].

Product Specifications

CAS Number

[405911-17-3]

UNSPSC

12352005

Hazard Statement

H302, H318, H413

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/GW3965-hydrochloride.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4.[H]Cl

Molecular Formula

C33H32Cl2F3NO3

Molecular Weight

618.51

Precautions

H302, H318, H413

References & Citations

[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60 (6), 616-621.|[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1 (5), 442-456.|[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117 (21), 5751-5761.|[4]Collins JL, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45 (10) :1963-6.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

BioRxiv. 2023 Mar 10.|Cytokine. 2025 May 7:191:156955.|Environ Int. 2024 Nov 26:194:109168.|Environ Sci Technol. 2025 May 6;59 (17) :8439-8450.|Immun Inflamm Dis. 2025 Aug;13 (8) :e70243.|Int Immunopharmacol. 2026 Jan 1;168 (Pt 2) :115878.|J Transl Med. 2025 May 14;23 (1) :542.|Nat Commun. 2025 Nov 6;16 (1) :9805.|Radboud University Nijmegen. 2021 Mar.|Viruses. 2022 Mar 3;14 (3) :514.|Am J Physiol Endocrinol Metab. 2019 Jun 1;316 (6) :E1136-E1145. |Bioconjug Chem. 2015 Nov 18;26 (11) :2216-22. |Biogerontology. 2025 Jan 31;26 (2) :49.|Brain Behav Immun. 2025 Aug 21:106089.|Cancer Lett. 2023 Jun 28:564:216208.|Cell Death Differ. 2020 Aug;27 (8) :2433-2450. |J Am Heart Assoc. 2021 May 18;10 (10) :e018455.|J Ethnopharmacol. 2023 Oct 28:315:116684.|MedComm (2020) . 2025 Sep 27;6 (10) :e70411.|Sci Adv. 2022 Jul 15;8 (28) :eabn5295.|SSRN. 2025 Aug 13.|Theranostics. 2020 Jul 11;10 (19) :8834-8850. |Vet Microbiol. 2024 Jan:288:109948.

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