CH 275

CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM[1]. CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively[2]. CH 275 can be used for the research of alzheimer’s disease[3].

Product Specifications

CAS Number

[174688-78-9]

UNSPSC

12352209

Target

Somatostatin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ch-275.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@H](C(N1)=O)CO)=O)([H])[C@H](O)C)=O)CC2=CC=CC=C2)=O)([H])[C@H](O)C)=O)CC(C=C3)=CC=C3CNC(C)C)[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H]1C(O)=O)N)=O)CCCCN)=O)CC4=CC=CC=C4)=O)CC5=CC=CC=C5)=O)CC6=CNC7=CC=CC=C67

Molecular Formula

C74H96N14O15S2

Molecular Weight

1485.77

References & Citations

[1]J E Rivier, et al. Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1) . J Med Chem. 2001 Jun 21;44 (13) :2238-46.|[2]L Chen, et al. Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem Biophys Res Commun. 1999 May 19;258 (3) :689-94.|[3]Per Nilsson, et al. Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid β-degrading enzyme, in brain.