Kojic acid (Standard)

Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields[1].

Product Specifications

CAS Number

[501-30-4]

UNSPSC

12352005

Target

CDK; NF-κB; Parasite; Reference Standards; Tyrosinase

Type

Reference Standards

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kojic-acid-standard.html

Smiles

O=C1C=C(CO)OC=C1O

Molecular Formula

C6H6O4

Molecular Weight

142.11

References & Citations

[1]Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183.|[2]Burnett C L, et al. Final report of the safety assessment of kojic acid as used in cosmetics[J]. International journal of toxicology, 2010, 29 (6_suppl) : 244S-273S.|[3]Saeedi M, et al. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomed Pharmacother. 2019 Feb;110:582-593. doi: 10.1016/j.biopha.2018.12.006.|[4]Kim T Y, et al. Nematicidal activity of kojic acid produced by Aspergillus oryzae against Meloidogyne incognita[J]. Journal of Microbiology and Biotechnology, 2016, 26 (8) : 1383-1391.|[5]Zilles J C, et al. Biological activities and safety data of kojic acid and its derivatives: A review[J]. Experimental dermatology, 2022, 31 (10) : 1500-1521.|[6]Kai H, et al. Assessment of the effect of arbutin isomers and kojic acid on melanin production, tyrosinase activity, and tyrosinase expression in B16-4A5 and HMV-II melanoma cells[J]. Planta Medica Letters, 2015, 2 (01) : e39-e41.|[7]Karakaya G, et al. Synthesis and cytotoxic evaluation of kojic acid derivatives with inhibitory activity on melanogenesis in human melanoma cells[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 2018, 18 (15) : 2137-2148.|[8]Khan A, et al. Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2021 Oct;58 (10) :5127-5140.