Amino-PEG10-amine

Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES) -based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

Product Specifications

CAS Number

[928292-69-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amino-peg10-amine.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

Molecular Formula

C22H48N2O10

Molecular Weight

500.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8 (4) :707-15.