NSC666715
Product Specifications
UNSPSC Description
NSC666715 is a strand-displacement activity of DNA polymerase inhibitor. NSC666715 potentiates Temozolomide (HY-17364)-induced DNA damage, cell senescence and apoptosis. NSC666715 can be used for study colorectal cancer[1].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc666715.html
Smiles
O=S(C1=CC(C)=C(Cl)C=C1S)(NC2=NN=C(NC3=CC=C(Cl)C=C3)N2)=O
Molecular Weight
430.33
References & Citations
[1]Jaiswal AS, et al. NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells. PLoS One. 2015;10(5):e0123808. Published 2015 May 1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120105/NSC666715-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120105/
Clinical Information
No Development Reported
CAS Number
170747-33-8
Curated Selection
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