NSC666715

NSC666715 is a strand-displacement activity of DNA polymerase inhibitor. NSC666715 potentiates Temozolomide (HY-17364) -induced DNA damage, cell senescence and apoptosis. NSC666715 can be used for study colorectal cancer[1].

Product Specifications

CAS Number

[170747-33-8]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc666715.html

Smiles

O=S(C1=CC(C)=C(Cl)C=C1S)(NC2=NN=C(NC3=CC=C(Cl)C=C3)N2)=O

Molecular Formula

C15H13Cl2N5O2S2

Molecular Weight

430.33

References & Citations

[1]Jaiswal AS, et al. NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells. PLoS One. 2015;10 (5) :e0123808. Published 2015 May 1.