NSC666715
NSC666715 is a strand-displacement activity of DNA polymerase inhibitor. NSC666715 potentiates Temozolomide (HY-17364) -induced DNA damage, cell senescence and apoptosis. NSC666715 can be used for study colorectal cancer[1].
Product Specifications
CAS Number
[170747-33-8]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc666715.html
Smiles
O=S(C1=CC(C)=C(Cl)C=C1S)(NC2=NN=C(NC3=CC=C(Cl)C=C3)N2)=O
Molecular Formula
C15H13Cl2N5O2S2
Molecular Weight
430.33
References & Citations
[1]Jaiswal AS, et al. NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells. PLoS One. 2015;10 (5) :e0123808. Published 2015 May 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items