Adrenosterone

Adrenosterone ((+) -Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells[1][2][3].

Product Specifications

CAS Number

[382-45-6]

Product Name Alternative

(+) -Adrenosterone

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Androgen Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/adrenosterone.html

Concentration

10mM

Purity

98.97

Solubility

DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

C[C@@]([C@](CC1)([H])[C@]2([H])CCC3=CC(CC[C@]3(C)[C@@]2([H])C4=O)=O)(C4)C1=O

Molecular Formula

C19H24O3

Molecular Weight

300.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Brooker L, et al. Carbon isotope ratio analysis of endogenous glucocorticoid urinary metabolites after cortisone acetate andadrenosterone administration for doping control. Drug Test Anal. 2012 Dec;4 (12) :951-61.|[2]Choudhary MI, et al. Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans. Steroids. 2007 Dec;72 (14) :923-9.|[3]Joji Nakayama, et al. A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial-Mesenchymal Transition and Metastatic Dissemination. Mol Cancer Res. 2020 Mar;18 (3) :477-487.