Neplanocin A

Neplanocin A ((-) -Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM) . Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis[1].

Product Specifications

CAS Number

[72877-50-0]

Product Name Alternative

(-) -Neplanocin A

UNSPSC

12352005

Target

Antibiotic; Orthopoxvirus

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/neplanocin-a.html

Purity

99.76

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C(N)N=CN=C23

Molecular Formula

C11H13N5O3

Molecular Weight

263.25

References & Citations

[1]Borchardt RT, Keller BT, Patel-Thombre U. Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells. J Biol Chem. 1984 Apr 10;259 (7) :4353-8.