Human Tau-441 K18 Pre-formed Fibrils Protein, Tag Free

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hype rphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Product Specifications

Background

Specifications

This protein carries no "tag". The protein has a calculated MW of 13.8 kDa.

Accession Number

P10636-8

Expression Region

Gln 244 - Glu 372

Host

E. coli

Target

Tau

Conjugation

Unconjugated

Tag

Native

Source

Human

Applications

1. Sonication Conditions, Dissolution, Aliquoting, Storage, and Notes for PFFThawing:Aliquoting:Storage:Sonication:Note:2. Recommendations for PFF Use in Animal ModelsMinimize Freeze-Thaw Cycles:PFF Maintenance During Injections:

Stability

The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C; The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions; The sonicated fibril should be stored at -70°C for not more than 8 weeks.