2′,2′-Difluorodeoxyuridine (Standard)

2′,2′-Difluorodeoxyuridine (Standard) is the analytical standard of 2′,2′-Difluorodeoxyuridine. This product is intended for research and analytical applications. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026) . 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells.

Product Specifications

CAS Number

[114248-23-6]

Product Name Alternative

DFdU (Standard) ; 2',2'-Difluoro-2'-deoxyuridine (Standard)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Drug Metabolite; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-2-difluorodeoxyuridine-standard.html

Purity

99.81

Smiles

O=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)C=CC1=O

Molecular Formula

C9H10F2N2O5

Molecular Weight

264.18

Precautions

H315, H319, H335

References & Citations

[1]Pauwels B, et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother Pharmacol. 2006 Aug;58 (2) :219-28.