ZEN-3862
ZEN-3862 is a BET inhibitor with IC50s of 0.16 and 0.13 μM for BRD4 (BD1) and BRD4 (BD2), respectively. ZEN-3862 can be used to form PROTACs to induce degradation of BRD4[1].
Product Specifications
CAS Number
[1952264-33-3]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zen-3862.html
Purity
98.86
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C=CC(C1=C(C)ON=C1C)=C2)N2CC3=CC(F)=C(C4OC4)C=C3
Molecular Formula
C19H17FN2O3
Molecular Weight
340.35
References & Citations
[1]Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61 (18) :8202-8211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Curated Selection
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