Pinocembrin chalcone

Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes[1][2].

Product Specifications

CAS Number

[4197-97-1]

Product Name Alternative

2',4',6'-Trihydroxychalcone

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

AMPK; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pinocembrin-chalcone.html

Purity

98.74

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(O)C=C(O)C=C1O)/C=C/C2=CC=CC=C2

Molecular Formula

C15H12O4

Molecular Weight

256.25

Precautions

H315, H319, H335

References & Citations

[1]P D Bremner, et al. Pinocembrin Chalcone: An Antibacterial Compound From Helichrysum Trilineatum. Planta Med. 1998 Dec;64 (8) :777.|[2]Shin J, et al. Antidiabetic effects of trihydroxychalcone derivatives via activation of AMP-activated protein kinase[J]. Journal of Industrial and Engineering Chemistry, 2018, 60: 177-184.