Gemifloxacin (mesylate)

Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections[1][2][3].

Product Specifications

CAS Number

[210353-53-0]

Product Name Alternative

SB-265805S; LB-20304a

UNSPSC

12352005

Hazard Statement

H341, H361, H373

Target

Antibiotic; Bacterial; DNA/RNA Synthesis; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Gemifloxacin-mesylate.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(CN)/C(C4)=N/OC)=N3)C1=O)O.CS(=O)(O)=O

Molecular Formula

C19H24FN5O7S

Molecular Weight

485.49

Precautions

H341, H361, H373

References & Citations

[1]Hong CY. Discovery of gemifloxacin (Factive, LB20304a) : a quinolone of a new generation. Farmaco. 2001 Jan-Feb;56 (1-2) :41-4.|[2]Allen A, Kim I, et al. Multiple-dose pharmacokinetics and tolerability of gemifloxacin administered orally to healthy volunteers. Antimicrob Agents Chemother. 2001 Feb;45 (2) :540-5.|[3]Erdem M, et al. Ingestion of the anti-bacterial agent, gemifloxacin mesylate, leads to increased gst activity and peroxidation products in hemolymph of Galleria mellonella l. (lepidoptera: pyralidae) . Arch Insect Biochem Physiol. 2016 Dec;93 (4) :202-209.