Ingenol Mebutate

Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

Product Specifications

CAS Number

[75567-37-2]

Product Name Alternative

Ingenol 3-angelate; PEP005

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PKC

Type

Natural Products

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Ingenol-Mebutate.html

Purity

99.65

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C/C=C(C)\C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(CO)=C[C@@](C3=O)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C)=O

Molecular Formula

C25H34O6

Molecular Weight

430.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Kedei N, et al. Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Res. 2004 May 1;64 (9) :3243-55.|[2]Hampson P, et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood. 2005 Aug 15;106 (4) :1362-8.|[3]Ghoul A, et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. Cancer Res. 2009 May 15;69 (10) :4260-9.