N-Biotinyl p-aminophenyl arsenic acid

N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols. N-Biotinyl p-aminophenyl arsenic acid decreases the Rbungarotoxin-binding sites in reduced Torpedo nicotinic receptors (IC50 is 10-300 nM), and protects the receptor from irreversible alkylation by bromoacetylcholine[1].

Product Specifications

CAS Number

[212391-23-6]

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

NAChR

Type

Dye Reagents

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-biotinyl-p-aminophenyl-arsenic-acid.html

Purity

98.13

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=[AsH](O)C(C=C1)=CC=C1NC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O

Molecular Formula

C16H22AsN3O4S

Molecular Weight

427.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Moaddel R, et al., Novel biotinylated phenylarsonous acids as bifunctional reagents for spatially close thiols: studies on reduced antibodies and the agonist binding site of reduced Torpedo nicotinic receptors. Bioconjug Chem. 1999 Jul-Aug;10 (4) :629-37.