Recombinant Human B-Cell Maturation Antigen/TNFRSF17
Product Specifications
Background
B-Cell Maturation Antigen (BCMA), encoded by the TNFRSF17 gene in humans. It is a member of the TNF receptor superfamily and a type III membrane protein containing one extracellular cysteine rich domain. It is expressed on mature B-cells and other B-cell lines. BCMA can binds to TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, and has functions that promotes B-cell survival, plays a role in the regulation of humoral immunity, and activates NF-kappa-B and JNK BCMA.
Product Name Alternative
TNFRSF17, BCM, CD269
Gene ID
608
UniProt
Q02223
Target
AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA
Purification
> 98 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rHuBCMA as determined by LAL method.
Bioactivity
4
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 5.4 kDa, a single non-glycosylated polypeptide chain containing 50 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 30 % acetonitrile, 0.1 % TFA.
Host or Source
Escherichia coli
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