ML-290

ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

Product Specifications

CAS Number

[1482500-76-4]

UNSPSC

12352005

Target

RXFP Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ML-290.html

Purity

99.81

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(S(=O)(C(F)(F)F)=O)=CC=C1)C2=C(NC(C3=CC=CC=C3OC(C)C)=O)C=CC=C2

Molecular Formula

C24H21F3N2O5S

Molecular Weight

506.49

References & Citations

[1]Wilson KJ, et al. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem. 2018 Aug 5;156:79-92.