ML-290
ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.
Product Specifications
CAS Number
[1482500-76-4]
UNSPSC
12352005
Target
RXFP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ML-290.html
Purity
99.81
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(S(=O)(C(F)(F)F)=O)=CC=C1)C2=C(NC(C3=CC=CC=C3OC(C)C)=O)C=CC=C2
Molecular Formula
C24H21F3N2O5S
Molecular Weight
506.49
References & Citations
[1]Wilson KJ, et al. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem. 2018 Aug 5;156:79-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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