WNK-IN-1

WNK-IN-1 (compound 7) is a ATP noncompetitive With-No-Lysine (WNK) kinase inhibitor (IC50=95 nM) . WNK-IN-1 can be used to regulate cardiovascular homeostasis[1].

Product Specifications

CAS Number

[2125724-72-1]

UNSPSC

12352005

Target

WNK Kinase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/wnk-in-1.html

Purity

98.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(CNCC1=CN(C2=C1C=CC=C2)C3=CC(C4=CC=CC(OC)=C4)=NC=C3C)C

Molecular Formula

C26H29N3O

Molecular Weight

399.53

References & Citations

[1]Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60 (16) :7099-7107.