WNK-IN-1
WNK-IN-1 (compound 7) is a ATP noncompetitive With-No-Lysine (WNK) kinase inhibitor (IC50=95 nM) . WNK-IN-1 can be used to regulate cardiovascular homeostasis[1].
Product Specifications
CAS Number
[2125724-72-1]
UNSPSC
12352005
Target
WNK Kinase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/wnk-in-1.html
Purity
98.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(CNCC1=CN(C2=C1C=CC=C2)C3=CC(C4=CC=CC(OC)=C4)=NC=C3C)C
Molecular Formula
C26H29N3O
Molecular Weight
399.53
References & Citations
[1]Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60 (16) :7099-7107.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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