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PSI-697

PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].

Product Specifications

CAS Number

[851546-61-7]

Product Name Alternative

P-Selectin Inhibitor

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

P-selectin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PSI-697.html

Purity

99.79

Solubility

DMSO : ≥ 45.8 mg/mL

Smiles

O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O

Molecular Formula

C21H18ClNO3

Molecular Weight

367.83

Precautions

H302, H315, H319

References & Citations

[1]Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 [2- (4-chlorobenzyl) -3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther.|[2]Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97 (3) :400-7.|[3]Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44 (3) :625-32.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-15526/PSI-697-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15526/PSI-697-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Curated Selection

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