Alloxazine

Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA) -mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].

Product Specifications

CAS Number

[490-59-5]

Product Name Alternative

Isoalloxazine

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alloxazine.html

Purity

99.46

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1)N=C2NC3=CC=CC=C3N=C2C1=O

Molecular Formula

C10H6N4O2

Molecular Weight

214.18

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47 (5) :801-14.|[2]Shin HK, et al. Role of adenosine A (2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278 (2) :H339-44.