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MC-1-F2

MC-1-F2 is a FOXC2 inhibitor. MC-1-F2 shows a binding affinity (Kd) of 26 μM for full-length FOXC2. MC-1-F2 reduces epithelial-mesenchymal transition (EMT) markers in breast cancer cells, suppresses cancer stem cell (CSC) properties and reduces invasiveness in castration-resistant prostate cancer (CRPC) cells. MC-1-F2 can be used for the study of CRPC and breast cancer[1][2].

Product Specifications

CAS Number

2376894-10-7

UNSPSC

12352005

Target

Cadherin; c-Myc

Type

Reference compound

Related Pathways

Apoptosis; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-1-f2.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(NCCCCNC1=NC(NC2=CC=C(C=C2)OC3=CC=CC=C3)=NC(N4CCN(CC4)C5=NC(NC6=CC=C(N7CCOCC7)C=C6)=NC(N)=N5)=N1)N

Molecular Formula

C37H46N16O2

Molecular Weight

746.87

References & Citations

[1]Castaneda M, et al. A FOXC2 inhibitor, MC-1-F2, as a therapeutic candidate for targeting EMT in castration-resistant prostate cancer. Bioorg Med Chem Lett. 2023 Jul 15;91:129369. |[2]Castaneda M, et al. A Forkhead Box Protein C2 Inhibitor: Targeting Epithelial-Mesenchymal Transition and Cancer Metastasis. Chembiochem. 2018 Jul 4;19 (13) :1359-1364.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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