Cobimetinib (R-enantiomer)
Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.
Product Specifications
CAS Number
[934660-94-3]
Product Name Alternative
GDC-0973 (R-enantiomer) ; XL-518 (R-enantiomer)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cobimetinib-_r-enantiomer_.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(F)C=CC(C(N2CC([C@H]3CCCCN3)(O)C2)=O)=C1NC4=CC=C(I)C=C4F
Molecular Formula
C21H21F3IN3O2
Molecular Weight
531.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72 (1) :210-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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