FAZ-3532

FAZ-3532 is a G3BP inhibitor (Kd = 0.54 μM) which binds to the NTF2L nsP3 binding pocket in G3BP1. FAZ-3532 disrupts the co-condensation of RNA, G3BP1, and caprin 1. FAZ-3532 inhibits G3BP-driven stress granule formation. FAZ-3532 can be studied as a powerful tool to probe the biology of stress granules and a promising interventions designed to modulate stress granule formation[1].

Product Specifications

CAS Number

[3036029-72-5]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/faz-3532.html

Purity

99.66

Solubility

DMSO : 116.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@H]([C@H](NC([C@H](C(C)(C)O)NC([C@H](CC(C)(C)C)F)=O)=O)C(N[C@H](C)C(N[C@@H](CCOC)C(N(C)CC1=CC=CC=C1)=O)=O)=O)C2=CC=CC=C2

Molecular Formula

C38H56FN5O7

Molecular Weight

713.88

References & Citations

[1]Brian D Freibaum, et al. Identification of small molecule inhibitors of G3BP-driven stress granule formation. J Cell Biol. 2024 Mar 4;223 (3) :e202308083. |[2]Kim, H. J., et al., (2025) . TBK1 is a signaling hub in coordinating stress-adaptive mechanisms in head and neck cancer progression. Autophagy, 1–23. Advance online publication.