Karenitecin
Product Specifications
UNSPSC Description
Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity.
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BNP_1350.html
Solubility
DMSO : 3.03 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC[Si](C)(C)C)C5=CC=CC=C5N=C4C3=C2)=O
Molecular Weight
448.59
References & Citations
[1]Yin MB, et al. Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol. 2000 Mar;57(3):453-9.|[2]Van Hattum AH, et al. New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer. Int J Cancer. 2000 Oct 15;88(2):260-6.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14812/Karenitecin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14812/Karenitecin-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
203923-89-1
Available Sizes
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