Karenitecin

Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity.

Product Specifications

CAS Number

[203923-89-1]

Product Name Alternative

Cositecan; BNP 1350

UNSPSC

12352005

Hazard Statement

H301

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BNP_1350.html

Purity

98.02

Solubility

DMSO : 3.03 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC[Si](C)(C)C)C5=CC=CC=C5N=C4C3=C2)=O

Molecular Formula

C25H28N2O4Si

Molecular Weight

448.59

Precautions

H301

References & Citations

[1]Yin MB, et al. Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol. 2000 Mar;57 (3) :453-9.|[2]Van Hattum AH, et al. New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer. Int J Cancer. 2000 Oct 15;88 (2) :260-6.