Karenitecin
Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity.
Product Specifications
CAS Number
[203923-89-1]
Product Name Alternative
Cositecan; BNP 1350
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BNP_1350.html
Purity
98.02
Solubility
DMSO : 3.03 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC[Si](C)(C)C)C5=CC=CC=C5N=C4C3=C2)=O
Molecular Formula
C25H28N2O4Si
Molecular Weight
448.59
Precautions
H301
References & Citations
[1]Yin MB, et al. Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol. 2000 Mar;57 (3) :453-9.|[2]Van Hattum AH, et al. New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer. Int J Cancer. 2000 Oct 15;88 (2) :260-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Topo I
Available Sizes
Curated Selection
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