LC3B rabbit pAb

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

Q9GZQ8

Swiss Prot

Q9GZQ8

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of MAP LC3β

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IF; IHC

Dilution

WB: 1:1000-2000 IHC: 1:200-500 IF 1:200

Molecular Weight

14,16kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

14,16kD

Fragment

IgG

Subcellular Location

Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor . Endomembrane system ; Lipid-anchor . Mitochondrion membrane ; Lipid-anchor . Cytoplasm, cytoskeleton . Cytoplasmic vesicle . LC3-II binds to the autophagic membranes. LC3-II localizes with the mitochondrial inner membrane during Parkin-mediated mitophagy (PubMed:28017329) . Localizes also to discrete punctae along the ciliary axoneme. .

Other Product Names

MAP1LC3B; MAP1ALC3; Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta