Sulfisoxazole (Standard)

Sulfisoxazole (Standard) is the analytical standard of Sulfisoxazole. This product is intended for research and analytical applications. Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].

Product Specifications

CAS Number

[127-69-5]

Product Name Alternative

Sulfafurazole (Standard)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Bacterial; Endothelin Receptor; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; GPCR/G Protein; Others

Field of Research

Cancer; Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/sulfisoxazole-standard.html

Purity

99.99

Smiles

O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O

Molecular Formula

C11H13N3O3S

Molecular Weight

267.30

Precautions

H315, H319, H335

References & Citations

[1]Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201 (1) : p. 228-34.|[2]Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10 (1) :1387.|[3]Shin JM, et al. Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD-L1. Adv Sci (Weinh) . 2022 Feb;9 (5) :e2103245. |[4]Syed H, et al. Sulfisoxazole, an endothelin receptor antagonist, protects retinal neurones from insults of ischemia/reperfusion or lipopolysaccharide. Neurochem Int. 2006 Jun;48 (8) :708-17.