HLI373 (dihydrochloride)
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents[1]. Antimalarial activity[2].
Product Specifications
CAS Number
1782531-99-0
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/hli373-dihydrochloride.html
Purity
98.32
Solubility
H2O : 38 mg/mL (ultrasonic; warming) |DMSO : 4 mg/mL (ultrasonic; warming)
Smiles
O=C1N=C2N(C)C3=C(C=CC=C3)C(NCCCN(C)C)=C2C(N1C)=O.[H]Cl.[H]Cl
Molecular Formula
C18H25Cl2N5O2
Molecular Weight
414.33
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
Frequently Asked Questions
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