HLI373 (dihydrochloride)

HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents[1]. Antimalarial activity[2].

Product Specifications

CAS Number

[1782531-99-0]

UNSPSC

12352005

Target

Apoptosis; MDM-2/p53; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/hli373-dihydrochloride.html

Purity

98.32

Solubility

H2O : 38 mg/mL (ultrasonic; warming) |DMSO : 4 mg/mL (ultrasonic; warming)

Smiles

O=C1N=C2N(C)C3=C(C=CC=C3)C(NCCCN(C)C)=C2C(N1C)=O.[H]Cl.[H]Cl

Molecular Formula

C18H25Cl2N5O2

Molecular Weight

414.33

References & Citations

[1]Jirouta Kitagaki, et al. Targeting Tumor Cells Expressing p53 With a Water-Soluble Inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7 (8) :2445-54.|[2]Jagrati Jain, et al. Inhibitors of Ubiquitin E3 Ligase as Potential New Antimalarial Drug Leads. BMC Pharmacol Toxicol. 2017 Jun 2;18 (1) :40.|[3]Ying Chen, et al. MDM2 Promotes Epithelial-Mesenchymal Transition and Metastasis of Ovarian Cancer SKOV3 Cells. Br J Cancer. 2017 Oct 10;117 (8) :1192-1201.