ISRE (Luc) HEK293 Reporter Cell
ISRE is a marker of interferon stimulated genes (ISGs), which mainly include enzymes that can inhibit virus replication. Type I (such as IFN α and IFN β) and type III interferon (such as IFN-λ) can activate STAT1 and STAT2, and the activated STAT1, STAT2, and IRF9 form a protein complex called ISGF3. The ISGF3 protein complex binds to the promoter containing the ISRE element (interferon-stimulated response element) and activates the expression of related genes.
Product Specifications
Background
ISRE is a marker of interferon stimulated genes (ISGs), which mainly include enzymes that can inhibit virus replication. Type I (such as IFN α and IFN β) and type III interferon (such as IFN-λ) can activate STAT1 and STAT2, and the activated STAT1, STAT2, and IRF9 form a protein complex called ISGF3. The ISGF3 protein complex binds to the promoter containing the ISRE element (interferon-stimulated response element) and activates the expression of related genes.
Host
HEK293
Origin Species
Human
Target
ISRE
Tag
Luc
Applications
• Screen for activators or inhibitors of Type I interferons.
Format
Liquid
Shipping Conditions
Dry ice
Storage Conditions
Frozen in liquid nitrogen
Package Size
1Vial*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CHEK-ATF134.pdf
Species
Human
Curated Selection
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