ABT-724 (trihydrochloride)

ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

Product Specifications

CAS Number

[587870-77-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/abt-724-trihydrochloride.html

Concentration

10mM

Purity

99.05

Solubility

DMSO : 20 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

[H]Cl.[H]Cl.[H]Cl.C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1

Molecular Formula

C17H22Cl3N5

Molecular Weight

402.75

Precautions

H315, H319, H335

References & Citations

[1]Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101 (17) :6758-63.