Cariporide
Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.
Product Specifications
CAS Number
159138-80-4
Product Name Alternative
HOE-642 (Free Base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Na+/H+ Exchanger (NHE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Cariporide.html
Purity
99.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC(N)=N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1
Molecular Formula
C12H17N3O3S
Molecular Weight
283.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Teshima Y, et al. Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation. 2003 Nov 4;108 (18) :2275-81.|[2]Chang HB, et al. Na (+) /H (+) exchanger in the regulation of platelet activation and paradoxical effects of cariporide. Exp Neurol. 2015 Oct;272:11-6.|[3]O'Donnell ME, et al. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab. 2013 Feb;33 (2) :225-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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