TC-I 2014
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].
Product Specifications
CAS Number
1221349-53-6
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc-i-2014.html
Purity
99.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC(C1=CC=CC=C1C2=CC(C(F)(F)F)=C3C(N=C(C4=NOC5(CCCCC5)C4)N3)=C2)(F)F
Molecular Formula
C23H19F6N3O
Molecular Weight
467.41
References & Citations
[1]Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54 (1) :233-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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