Zileuton
Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
Product Specifications
CAS Number
111406-87-2
Product Name Alternative
A 64077; Abbott 64077
UNSPSC
12352005
Hazard Statement
H302, H319, H350, H360
Target
Ferroptosis; Lipoxygenase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Zileuton.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1
Molecular Formula
C11H12N2O2S
Molecular Weight
236.30
Precautions
H302, H319, H350, H360
References & Citations
[1]Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10|[2]Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner|[3]Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10 (3) :e0121402
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-LOX
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