Zileuton

Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.

Product Specifications

CAS Number

[111406-87-2]

Product Name Alternative

A 64077; Abbott 64077

UNSPSC

12352005

Hazard Statement

H302, H319, H350, H360

Target

Ferroptosis; Lipoxygenase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Zileuton.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1

Molecular Formula

C11H12N2O2S

Molecular Weight

236.30

Precautions

H302, H319, H350, H360

References & Citations

[1]Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10|[2]Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner|[3]Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10 (3) :e0121402