SUVN-911

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1].

Product Specifications

CAS Number

[2414674-71-6]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/suvn-911.html

Concentration

10mM

Purity

99.40

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC1=NC=C(OC[C@H]2N[C@@H]3C[C@@H]3C2)C=C1.[H]Cl

Molecular Formula

C11H14Cl2N2O

Molecular Weight

261.15

References & Citations

[1]Ramakrishna Nirogi, et al. Discovery and Development of 3- (6-Chloropyridine-3-yloxymethyl) -2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911) : A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63 (6) :2833-2853.