Research Grade MEDI3185
MEDI3185haspicomolarbindingaffinitytohumanCXCR4andexhibitsnosignificantbindingtootherchemokinereceptorssuchasCCR4orCXCR3.InvitrostudiesdemonstratedthatMEDI3185inhibitedtumorcellmigration, blockedSDF-1inducedtumorcellsignalingandinducedapoptosisoftumorcells.TheMEDI3185epitopecomprisestheentireECL2sequence, lacksanyso-called'hot-spot'andisremarkablyresistanttomutations.ThestructureofMEDI3185variabledomainswasmodeled, andsuggestedaβ-strand/β-strandinteractionbetweenMEDI3185CDR3HandCXCR4ECL2, resultingindirectsterichindrancewithCXCR4ligandSDF-1.
Product Specifications
Expression System
Mammalian Cells
Host
Human
Target
Clonality
Monoclonal
Applications
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Purification
Protein A/G purified from cell culture supernatant.
Concentration
1mg/ml
Endotoxin
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Form
Liquid
Buffer
0.01M PBS, pH7.4.
Storage Conditions
Notes
For research use only. Not suitable for clinical or therapeutic use.
Buffer pH
0.01M PBS, pH7.4.
Species
Human
Isotype
IgG1
Available Sizes
Frequently Asked Questions
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