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Research Grade Sotigalimab

TheFDAhasgrantedanorphandrugdesignationtosotigalimab (APX005M) asapotentialtherapeuticoptionforpatientswithsofttissuesarcoma, accordingtoannouncementfromApexigenInc., thedrugdeveloper. Anovel, humanizedmonoclonalantibody, sotigalimabwasdesignedstimulateantitumorimmuneresponseandtotargetCD40, whichisakeyco-stimulatoryreceptorthatservestoactivateinnateandadaptiveimmunesystems.WhensotigalimabbindstoCD40onantigen-presentingcells, itinducesamultifacetedimmuneresponsethatbringsseveralcomponentsoftheimmunesystemtogethertoattackthecancer.

Product Specifications

Product Name Alternative

APX005M, APX-005, APX-005-M, APX-005M, CAS:2305607-45-6

Expression System

Mammalian Cells

Host

Humanized

Target

Tumornecrosisfactorreceptorsuperfamilymember5, B-cellsurfaceantigenCD40, Bp50, CD40Lreceptor, TNFRSF5, CDw40, CD40

Clonality

Monoclonal

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Purification

Protein A/G purified from cell culture supernatant.

Concentration

1.7mg/ml

Endotoxin

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Form

Liquid

Buffer

0.01M PBS, pH7.4.

Storage Conditions

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at4°C short term (1-2weeks) . Store at-20°C 12 months. Store at -808°C long term.

Notes

For research use only. Not suitable for clinical or therapeutic use.

Buffer pH

0.01M PBS, pH7.4.

Species

Human

Isotype

IgG1-Kappa

Available Sizes

Frequently Asked Questions

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