Research Grade Aducanumab

Aducanumab (brandname:Aduhelm) isanamyloidbeta-directedmonoclonalantibodythattargetsamyloidbetainthebrainsofpeoplewithAlzheimer’storeduceitsbuildup.Aducanumabisamonoclonalantibody (aproteinthathelpsyourimmunesystemtargetotherproteins), anditisdesignedtohelpyourbodyremovesomethingcalledamyloidbetafromthebrain.AmyloidbetaisanimportantproteininvolvedintheprogressionofAlzheimer’sdisease.Aducanumabisgivenintravenously (infusedthroughavein) monthly.AducanumabdoesnotcureAlzheimer’sdisease, butone (oftwo) largeclinicalstudiessuggeststhataducanumabmayslowtheprogressionoftheearliestsymptomsofAlzheimer’sdisease.

Product Specifications

Product Name Alternative

BART, BIIB-037, CAS:1384260-65-4

Expression System

Mammalian Cells

Host

Human

Target

AICD-57, A4, Beta-CTF, Proteasenexin-II, Gamma-CTF (50), ABPP, S-APP-beta, APP, Abeta40, Abeta42, AID (59), Amyloidintracellulardomain59, AID (57), S-APP-alpha, Gamma-CTF (59), Beta-secretaseC-terminalfragment, Amyloid-betaprecursorprotein, Amyloidprecursorprotein, Beta-APP42, PreA4, Alzheimerdiseaseamyloidprotein, APPI, PN-II, AICD-59, Alpha-secretaseC-terminalfragment, Amyloid-betaA4protein, Amyloidintracellulardomain57, CVAP, Amyloidintracellulardomain50, Beta-APP40, AD1, Cerebralvascularamyloidpeptide, AID (50), Alpha-CTF, Gamma-CTF (57), AICD-50

Clonality

Monoclonal

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Purification

Protein A/G purified from cell culture supernatant.

Concentration

2.3mg/ml

Endotoxin

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Form

Liquid

Buffer

0.01M PBS, pH7.4.

Storage Conditions

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at4°C short term (1-2weeks) . Store at-20°C 12 months. Store at -415°C long term.