Votoplam
Votoplam (PTC518) (Example 37) is an HTT gene regulator with an IC50 ≤ 0.1 μM. Votoplam can be used in the research of Huntington's disease[1].
Product Specifications
CAS Number
2407849-89-0
Product Name Alternative
PTC518
UNSPSC
12352005
Target
Huntingtin
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/votoplam.html
Purity
99.51
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C(C2=NN=C3C(N=NN3C4CC(C)(C)NC(C)(C4)C)=C2)C=CC(N5N=CC=N5)=C1
Molecular Formula
C21H25N9O
Molecular Weight
419.48
References & Citations
[1]Sydorenko, et al. Preparation of heterocyclic and heteroaryl compounds for treating Huntington's disease. World Intellectual Property Organization, WO2020005873 A1. 2020-01-02.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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