Research Grade Coltuximab
Coltuximabravtansine (SAR3419) isanantibody-drugconjugate (ADC) targetingCD19createdbyconjugatingaderivativeofthepotentmicrotubule-actingcytotoxicagent, maytansine, toaversionoftheanti-CD19antibody, anti-B4, thatwashumanizedasanIgG1byvariabledomainresurfacing.Fourdifferentlinker-maytansinoidconstructsweresynthesized (average∼3.5maytansinoids/antibodyforeach) toevaluatetheimpactoflinker-payloaddesignontheactivityofthemaytansinoid-ADCstargetingCD19.Anti-CD19humanizedmonoclonalantibodyconjugatedtoDM4.
Product Specifications
Product Name Alternative
SAR3419, CAS:1269764-99-9
Expression System
Mammalian Cells
Host
Chimeric
Target
CD19, DifferentiationantigenCD19, T-cellsurfaceantigenLeu-12, B-lymphocyteantigenCD19, B-lymphocytesurfaceantigenB4
Clonality
Monoclonal
Applications
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Purification
Protein A/G purified from cell culture supernatant.
Concentration
1 mg/mL
Purity
> 95% as determined by SDS-PAGE.
Form
Liquid
Buffer
0.01M PBS, pH7.4.
Storage Conditions
Notes
For research use only. Not suitable for clinical or therapeutic use.
Species
Human
Available Sizes
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