DKK-1

Intended use: Dickkopf-1 (DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression. DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity. Intended applications: Atherosclerosis Rheumatoid arthritis Myeloma bone disease Diffuse idiopathic skeletal hyperostosis Ankylosing spondylitis Monoclonal gammopathy of undetermined significance Glucocorticoid induced osteoporosis Oncology