Intact Fibroblast Growth Factor 23

Intended use: FGF23 (fibroblast growth factor 23) is a member of the fibroblast growth factor family and controls phosphate and vitamin D homeostasis. The full-length protein comprises 251 amino acids including a 24 amino acid signal peptide. The N-terminal FGF region of FGF23 is separated from the C-terminal region by a proteolytic cleavage site. A fraction of FGF23 is proteolytically processed between arginine179 and serine180 to generate N-terminal and Cterminal fragments. Therefore, the main forms of FGF23 present in human circulation are hormonally intact FGF23 and inactive N-terminal and C-terminal fragments. FGF23 binds to FGF receptor 1c (FGFR1c) with its N-terminal region, while the C-terminal region interacts with the co-receptor α-Klotho to confer high-affinity binding to the receptor. FGFR1c and α-Klotho are expressed in the distal nephron and the parathyroid gland. Co-receptor independent signaling of FGF23 has been described for other FGFRs, which are expressed in a variety of tissues. The main source of FGF23 are osteocytes in the bone. Intended applications: Bone diseases Cancer Cardiovascular diseases Endocrine disorders Metabolic disorders Kidney diseases