C3a Mouse (TECO®)

C3 is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue‐specific and is modulated in response to a variety of stimulatory agents. During complement activation, C3 is proteolytically cleaved resulting in release of the anaphylatoxic peptide C3a.   C3a is a small polypeptide consisting of 74 amino acids. C3a itself is very short‐lived and in serum cleaved rapidly into the more stable C3a‐desArg (also called acylation stimulating protein, ASP) . Therefore, measurement of C3a‐desArg allows reliable conclusions about the level of complement activation in the samples.